Al Ahly will host the South African giants on Saturday night at Al Ahly Stadium and they will meet again a week later in South Africa.
The two teams will face off on Saturday night at Al Ahly stadium in El Salam City in the first leg of the quarter-finals.
Al Ahly's head coach Pitso Mosimane spoke after the game and hailed the performance of his players in the game after losing five points in the last two games.
The details have been confirmed for the quarter-finals of this season's CAF Champions League competition.
Smouha were the first team in the league to get the three points against Al Ahly this season, having secured a late 2-1 win over the Red Eagles.
The Red Eagles have been struggling since they won the derby over Zamalek on 18 April, having achieved just 7 points from their last five matches.
Sunday's game could witness Awwad's first appearance for Zamalek since the first of February 2020.
In a mega ceremony, Al Ahly announced the future plans for the club fans' long-awaited dream project of seeing their club having its own stadium.
Al Ahly were held to a 1-1 draw against El Gouna on Friday night in the Egyptian League at Al Ahly stadium.
CAF Champions League title-holders Al Ahly will face South Africa's Mamelodi Sundowns in the CAF Champions League quarter-finals.
Al Ahly added the league title to the Egyptian Cup title, which they achieved in March to complete the domestic double.
The French head coach stated that his team will fight to win the League and Cup titles this season.
The loss to Smouha is Al Ahly's first defeat in the Egyptian League since the appointment of Pitso Mosimane as Al Ahly's head coach.
The Egyptian League's semi-finals matches will be played between 4 and 10 May.
It was clear that Al Ahly will face difficulties in the match despite going to the game in high spirits after a vital win over Zamalek in Cairo derby.
The first derby in Ramadan goes back to 7 April 1957 and ended with a 2-0 win for the Red Devils thanks to a brace from the club's legend El-Dhizhui.
Al Ahly will count on their back-up goalkeeper Ali Lotfy, who will appear in the derby for the first time in his career.
Zamalek enter the game in high spirits as they are on an impressive run under the leadership of Patrice Carteron.
If the game finished in a draw, the two teams will face off again in a match to decide the league champion.
Al Ahly and Zamalek booked their places in the Egyptian Cup round of 16 after a strong start to the competition.