Pique will miss Tuesday's crucial Champions League clash against Dynamo Kiev with a calf injury, the club said on Sunday.
The Spanish giants lost the third match in the league this season and they are fourth in the standings with 17 points after 10 matches.
Koeman cursed his side’s profligacy after they drew 1-1 at Alaves on Saturday, dropping points for the fourth game in a row in La Liga.
Neto made an embarrassing gaffe as his side were held to a 1-1 draw away to Alaves on Saturday, despite playing the final half an hour with an extra man.
Real Madrid manager Zinedine Zidane believes that the player will be fit for Friday's encounter.
Atletico Madrid thrashed Alaves 4-0 on Saturday to keep alive their faint hopes of winning the La Liga title as they stayed 10 points behind leaders Barcelona in second place in the standings.
Real Madrid's 'BBC' strikeforce hit back with a vengeance when Cristiano Ronaldo, Gareth Bale and Karim Benzema all scored in a 4-0 win over Alaves
LIorente is a Real Madrid academy product, he joined the club when he was just 13.
Real Madrid succeeded to secure a valuable away three points by beating Alaves 2-1 in the 6th round of the Spanish League (La Liga).
Real Madrid coach Zinedine Zidane will go up against his son Enzo for the first time when he takes his struggling Spanish champions to Alaves on Saturday.
Zinedine Zidane revealed that he is very confident of his team, and goals will come if his team keeps creating chances.
Southampton announced this Friday that Mauricio Pellegrino will be the new head coach of the club for the next three years, Pellegrino will return to England after having previously working as an assistant manager for Liverpool under former coach, Rafael