Visitors Freiburg will feel little pressure as they seek their first victory in Dortmund in 20 years.
Robert Lewandowski netted twice as Bayern Munich retained the German Super Cup with a 3-1 win at Borussia Dortmund on Tuesday in a high-tempo encounter.
Moukoko became the youngest player to score in the Bundesliga but ended up on the losing side as they slumped to a 2-1 defeat at Union Berlin.
Dortmund were left to rue their missed chances after losing 3-2 at home to old rivals Bayern Munich.
Bayern Munich wasted a two-goal lead and needed a lucky 82nd- minute winner from Joshua Kimmich to beat Borussia Dortmund 3-2.
In-demand winger Jadon Sancho says he is happy at Borussia Dortmund and is enjoying helping some of the younger players develop at the Bundesliga club.
Borussia Dortmund and Hertha Berlin took a knee in solidarity with the Black Lives Matter protests on Saturday as players across the Bundesliga showed support for demonstrations sparked by the death of George Floyd.
Norwegian sensation Erling Braut Haaland stole the limelight Saturday as the German Bundesliga became the first major European football league to return since the coronavirus lockdown, with teams playing in empty, echoing stadiums.
Bayern Munich are in pole position to win an eighth straight title, but Borussia Dortmund lead the chasing pack and are spearheaded by Erling Braut Haaland as the Bundesliga comes out of its coronavirus-enforced hibernation this weekend.
Paris Saint-Germain's Champions League last 16 second leg at home to German club Borussia Dortmund on Wednesday will be played behind closed doors because of the coronavirus outbreak, Paris police said on Monday.
The return of Neymar from a rib injury in time for Tuesday's Champions League last 16 clash at Borussia Dortmund "changes almost everything... and brings a lot of confidence" to his Paris Saint-Germain team-mates, coach Thomas Tuchel said.
Packed with passionate home fans, Borussia Dortmund's imposing south stand - dubbed 'The Yellow Wall' - is the 'gigantic monster' lurking to test Paris Saint-Germain stars like Neymar and Kylian Mbappe in the Champions League on Tuesday.
Nineteen-year-old Erling Haaland followed up his debut hat-trick for Borussia Dortmund by scoring two more, again from the substitute’s bench, in a 5-1 demolition of Cologne in the Bundesliga on Friday.
Tottenham Hotspur beat hosts Borussia Dortmund 1-0 on Tuesday thanks to a clinical Harry Kane finish, to stroll into the Champions League quarter-finals for only the second time in their history with a 4-0 aggregate victory.
Borussia Dortmund are likely to have captain Marco Reus back in the squad for Friday's match at Augsburg and his return could not have come sooner for the Bundesliga leaders.
Borussia Dortmund were in the running for three trophies only weeks ago but a recent slump in form has left them in a situation where they must beat bottom club Nuremberg on Monday to try and turn their faltering season around.
The 18-year-old has also featured regularly in the Champions League, making 28 appearances in all competitions this season.
Bundesliga leaders Borussia Dortmund inexplicably surrendered a three-goal lead in the second half to draw 3-3 against Hoffenheim on Saturday after completely dominating for more than an hour.
Chelsea confirmed the signing of U.S. international winger Christian Pulisic from Borussia Dortmund on Wednesday, making the 20-year-old the most expensive American soccer player in history.
Spanish striker Paco Alcacer is making his loan deal at Borussia Dortmund permanent, the Bundesliga leaders announced on Friday.