Al Hilal qualified for the competition after dominating Asian football last season to win the AFC Champions League title.
Al-Ahly strikers Junior Ajayi and Walid Azaro will miss the game, as they failed to recover from their muscle injuries.
Ekramy couldn’t save an easy shot from Esperence’s midfielder, Ghailene Chaaleli, that led to Esperence’s second goal.
Esperance goes into the second leg in a better position than many had expected, with a 2-2 draw in the first leg.
Sherif Ekramy made a mistake that led to Esperence’s second goal.
Al Ahly faces Esperence September 15-17 at Borg El Arab Stadium in Alexandria in first leg of CAF Champions League quarter-finals