Man City moved 13 points clear at the top with a 2-0 win at Crystal Palace on Saturday.
Treble-chasing Manchester City face a Tottenham side desperate to end their trophy drought in the League Cup final.
Guardiola said he still has trust in Raheem Sterling but the England forward must rediscover his best form to play more regularly.
Manchester City scored twice in the second half through Mahrez and Foden to beat Borussia Dortmund on Wednesday and reach the Champions League semi-finals.
James Maddison will be back in Leicester's squad for Saturday's clash against Manchester City.
Manchester City, Manchester United, Leicester and Chelsea currently occupy the top four places in the English top-flight
Campaigners have long called for a reduction in the amount of heading done in training at senior level to cut the risk of long-term brain injury.
Sancho, a product of City's academy, rejected a new contract at the Premier League club when he was 17 to join Dortmund in 2017.
The British government last month set out a four-stage easing of England's COVID-19 lockdown restrictions.
Brighton host a Southampton side that have won just once in their last 11 games, while Newcastle face Aston Villa.
Guardiola says Manchester United will be "difficult" opponents despite a huge gulf in form between the two sides ahead of Sunday's derby.
City remain on course for an unprecedented quadruple of trophies.
Real's task appeared to have been made much easier after Atalanta's Remo Freuler was sent off in the 17th minute.
Guardiola's men hold a five-point lead at the top of the table with a game in hand over second-placed Manchester United.
Yaya Toure has been named assistant manager of Olimpik Donetsk, the Ukrainian Premier League club said on Wednesday.
Should City win on Sunday they would move 10 points clear of Liverpool having also played one game fewer.
Klopp believes that his team is not showing the performance that makes them Premier League title contenders.
De Bruyne, 29, looked to have sustained a leg muscle injury and was replaced on the hour mark at the Etihad Stadium.
The 20-year-old midfielder scored his eighth goal of the season as City beat Premier League strugglers Brighton 1-0.
Manchester City owner Sheikh Mansour bin Zayed Al Nahyan is the new owner of the oldest existing version of the FA Cup trophy.