The defending champions squeezed past Iran's Foolad on Thursday to set up the meeting with the Qatari club in Doha, with the winners due to take on Japan's Urawa Red Diamonds over two legs in the final on April 29 and May 6.
The winner of the clash will face German giants Bayern Munich on 8 February in the semi-finals.
Al Ahly's best achievement came in 2006 when they won the bronze medal, becoming the first club from Africa to reach the podium.
The Red Eagles qualified to the competition after defeating arch-rivals, Zamalek, 2-1 in the CAF Champions League final.
Wales coach Warren Gatland piled the pressure on Ireland ahead of the Six Nations Championship by installing them as favourites to win the World Cup in Japan later this year.
Tunisia head coach Nabil Maaloul has stepped down from his role with the national team to join Al Duhail as their new manager, the Qatari club has said.