The Spanish Football Federation on Friday banned him for two games after the Dutchman was sent off during his team's 2-1 defeat at Granada.
Solskjaer tried to placate angry fans of Europa League semi-final opponents Roma, who have accused the Manchester United boss of disrespecting their club.
Solskjaer said Rashford, 23, was available for the trip to Spain but might not be risked for the entire match.
Koeman praised his side for their never-say-die attitude after they reached the Copa del Rey final with a 3-0 win after extra-time over Sevilla.
Real Madrid endured their toughest test at Granada on Monday since La Liga restarted but showed real determination to grind out a 2-1 win and record their ninth consecutive victory as they moved within touching distance of reclaiming the title.
Messi is expected to take part in the second half against Granada for his first LaLiga appearance this season.
In A.D. 711, Islam made its entrance into the Iberian Peninsula.
Pro-animal rights activists protest before the Corpus Christi festival bullfight in Granada, Spain, where matadors perform with bulls.