The 30-year-old has scored 20 goals in 44 appearances for Liverpool this season, including six in his last seven, as the club seek to secure an unprecedented quadruple.
Klopp's side are bidding to become the first English club to lift all four major trophies in a single season.
With only one point separating City and Liverpool, Klopp praised his team's improvement and said both clubs have pushed each other to get better.
That was the ideal preparation for the seismic showdown with City, who also face Liverpool in the FA Cup semi-finals at Wembley on April 16.
The two teams are seperated by just a point with leaders City hoping they can restore some breathing space with a victory.
Liverpool boss Jurgen Klopp and Manchester City manager Pep Guardiola were outspoken critics of the previous refusal to adopt the change.
The 63-year-old German is due to start a two-year consultancy role after the season finishes.
Klopp believes his current Liverpool group is the best he has coached in his glittering career.
Despite his team winning their last four games, Liverpool manager Juergen Klopp says Manchester City will not be peering anxiously in their rear view mirror.
Klopp has a full squad at his disposal with Henderson back from injury, and forwards Salah and Sadio Mane making their first starts since returning from the AFCON in Liverpool's win over Burnley.
Liverpool will go in with increased confidence after they reached the League Cup final with a 2-0 win at Arsenal on Thursday.
The Merseyside club temporarily closed their training ground on Wednesday due to a rapidly growing number of suspected COVID-19 infections at the club.
The Egyptian winger is ready to support his team in their trip on Sunday to Stamford Bridge.
Salah is in a fantastic run of form in the league, leading the charts of goals and assists in the competition with 24 league goal contributions.
Klopp said on Friday that it was too difficult to prepare for Sunday's Premier League game at Tottenham Hotspur given the uncertainty around the opposition due to the COVID-19 outbreak.
The Egyptian was not happy with Klopp's decision and the coach was asked for an explanation after the match.
Alexander-Arnold praised the current form of his Egyptian teammate after Liverpool's 3-1 victory over Newcastle United on Thursday night.
Salah's goal took his tally in the Premier League this season to 15 goals.
Salah failed to maintain his great scoring form but he extended his lead as the Premier League top assist provider with 9 assists.
Klopp said he has spoken to Mane about how to deal with such situations.